Obesity management for kidney TRANSPLANTation (OK-TRANSPLANT 2)

Study Lead

Dr. Kristin Clemens

St. Joseph's Health Care London

Overview

This research is a smaller pilot study designed to pave the way for a larger clinical trial, with the goal to develop a weight management program tailored to patients with advanced kidney disease and obesity, aiming to support weight loss and improve their chances of receiving a kidney transplant.

For participants in the usual care group, they will only need to complete the informed consent process and a few questions regarding demographics/sarcopenia at the beginning of their time in the study and again 6 months later, at the end. Nothing will be expected of these participants at any other time throughout the study.

For participants in the intervention group, they will complete the same demographics/sarcopenia questions at the beginning and end of the 6 month study period and meet virtually with an intervention coach once a month (5-6 sessions).

Eligibility

To participate in this study, you must:

  • Be 18 years of age or older

  • Have a Body Mass Index (BMI) ≥ 35 kg/m²

  • Be either:

    • Currently receiving dialysis, or

    • Have a >10% risk of progressing to End-Stage Kidney Disease requiring renal replacement therapy (RRT) within 2 years

You cannot participate if you:

  • Have a known contraindication to GLP-1 receptor agonist (GLP-1RA) medications, such as:

    • A history of pancreatitis

    • A personal or family history of medullary thyroid cancer

    • A known hypersensitivity to GLP-1RA medications

  • Do not have access to drug benefits that cover semaglutide

  • Are pregnant or breastfeeding

  • Have Type 1 diabetes

  • Are currently enrolled in or planning to join another GLP-1RA or GLP-1RA/GIP study

Deadline: 10/31/2025
Study contact: heather.lapier@sjhc.london.on.ca

Type of Participation

Interview, Survey

Diagnosis

Chronic Kidney Disease

Treatment

Hemodialysis, Peritoneal Dialysis, Transplantation

Topic

CKD and Diet, Prevention, Quality of Life, Self-Management, Symptoms

Location

Alberta, British Columbia, Manitoba, New Brunswick, Newfoundland & Labrador, Northwest Territories, Nova Scotia, Nunavut, Ontario, Prince Edward Island, Quebec, Saskatchewan, Yukon

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